Unit - 1: Introduction to Medicinal Chemistry

Welcome Readers

In this post the authors of #smillingpharmacy has provided the detailed contents for Unit - I  of medicinal chemistry which is in accordance to #PCI syllabus. According to syllabus of unit-I it is divided into three heads viz., Introduction to medicinal chemistry, physio-chemical properties and Metabolism.

In introduction to medicinal chemistry following things are included

Definition, Medicinal chemistry concept

In Physio-chemical properties following things are included

• #Receptor, Classification, different types of binding, working of receptor
  
• Important definition like #Agonist, #Antagonist etc
• #Lipinski rule of 5
  
• #Ferguson principle
• Different physiochemical properties like #Solubility, #PartitionCoefficient, #Ionisation, #HydrogenBonding, #SurfaceActivity, #ProteinBinding, #Chelation, #Stereochemistry

In metabolism part following things are included

• Introduction, types of enzyme involved in metabolism
• #RedoxCycle
  
• #Phase-I metabolism which covers #Oxidation, #Reduction, #Hydrolysis etc with examples
  
• #Phase-II metabolism which covers different #conjugation reactions like #Glucuronidation etc with examples
  

"No word has any meaning" We give meaning to that word and get suffered internally.

Anand

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Introduction to Medicinal Chemistry

Receptor

Definition - #Affinity, #IntrinsicActivity, #Agonist, #Antagonist, #PartialAgonist, #InverseAgonsit

Types of receptor - #LigandGatedIonChannel, #G-ProteinCoupledReceptor, #KinaseReceptor, #NuclearReceptor

#DrugReceptorInteraction - #CovalentBonding, #IonicBonding, #Dipole-DipoleInteraction, #HydrogenBonding, #VanderVall'sInteraction,#HydrophicInteraction

Physicochemical properties in relation to biological action

#Ionization, #Solubility, #PartitionCoefficient, #Hydrogenbonding, #Proteinbinding, #Chelation, #Bioisosterism, #OpticalIsomerism and #GeometricalIsomerism.

Drug metabolism

#DrugMetabolism principles- Phase I and Phase II. #RedoxCycle

Factors affecting drug metabolism including stereo chemical aspects.